Tag Archives: drug

Baldness cure could come from side-effect of cancer drug

Baldness cure could come from side-effect of cancer drugA cure for baldness could be on the horizon after British scientists discovered that an osteoporosis drug stimulates hair growth three times quicker than other drugs. Around four in 10 men suffer male pattern baldness by the age of 45 and two thirds by the age of 60. At the moment only two drugs, minoxidil and finasteride, are available for the treatment of male pattern baldness (androgenetic alopecia) – the classic type of receding hair loss in men. But both have side effects and often produce disappointing results. The only other option open to patients losing their hair is transplantation surgery. To find a new treatment, scientists at Manchester University first studied a cancer drug called CsA, which has the embarrassing side-effect of substantial unwanted hair growth. They discovered the hair growth happens because the drug reduces the activity of a protein called SFRP1, which prevents the growth of hair follicles. Although CsA itself is not suitable as a baldness treatment because of its extreme side-effects, scientists found that a drug previously designed to treat osteoporosis, called WAY-316606, was even better at targeting the hair-suppressing protein. The inside of a human hair bulb Credit: Nathan John Hawkshaw  In tests, follicles donated by more than 40 patients undergoing hair transplant surgery were treated with the drug and and quickly went into the active phase of hair growth, sprouting 2mm of hair within just six days. Lead scientist Dr Nathan Hawkshaw said: “The drug also maintained more hair follicles to stay within the growth phase of the hair cycle compared to control. Not only this, we show that this drug effectively enhances hair shaft keratin production. “Collectively this suggests that WAY-316606 could be an effective therapeutic option for treating human hair growth disorders. “CsA takes at least six days to enhance human hair growth ex vivo whereas we see a significant increase in hair growth after two days with WAY-316606. “The fact this new agent, which had never even been considered in a hair loss context, promotes human hair growth is exciting because of its translational potential: It could one day make a real difference to people who suffer from hair loss.” The research also explains why CsA so often induces undesired hair growth in patients as it removes an inbuilt and potent molecular brake on human hair growth. The research was published in the journal Plos Biology.



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Canadian drug mule sentenced in Australia for cocaine cruise

Canadian drug mule sentenced in Australia for cocaine cruiseCANBERRA, Australia (AP) — A Canadian drug mule broke down in tears in an Australian court on Wednesday when she was sentenced to eight years in prison for her part in an attempt to smuggle cocaine worth $ 16 million into Sydney in luggage aboard a luxury cruise ship.



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Mexican drug kingpin behind DEA murder added to FBI most-wanted list

Mexican drug kingpin behind DEA murder added to FBI most-wanted listA veteran drug kingpin convicted over the murder of a DEA agent and then released on a technicality from a Mexican prison has been added to the FBI’s list of its 10 most-wanted fugitives. Rafael Caro Quintero now faces additional criminal charges unsealed in a federal court in Brooklyn, New York, and the US government increased the reward for his capture to $ 20m.



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Mexican drug lord among FBI 10 most wanted fugitives

Mexican drug lord among FBI 10 most wanted fugitivesWASHINGTON (AP) — A Mexican drug kingpin convicted in the 1985 killing of a DEA agent was added Thursday to the FBI's list of most-wanted fugitives.



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Fugitive Rafael Caro Quintero Speaks Out On Allegations Of Drug Trafficking

Fugitive Rafael Caro Quintero Speaks Out On Allegations Of Drug TraffickingRafael Caro Quintero, aka “The Prince,” is a fugitive on the U.S. Drug Enforcement Administration’s most-wanted list. The alleged leader of the world’s most powerful drug cartel gave an interview while hiding.



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Philippine leader demands review of dropped cases vs. alleged drug kingpins

Philippine leader demands review of dropped cases vs. alleged drug kingpinsPhilippine President Rodrigo Duterte has ordered a review of a decision by state prosecutors to dismiss complaints against several suspected drugs kingpins, amid outrage among the public and some of his allies about them walking free. A Department of Justice panel, citing weak evidence, cleared 22 suspects in a decision they made in December but was made public only on Monday in a document leaked to media. A self-confessed drug dealer was among those cleared.



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President Donald Trump Suggests Death Penalty For Drug Dealers

President Donald Trump Suggests Death Penalty For Drug DealersPresident Donald Trump suggested drug dealers in the United States should face harsher punishments, such as the death penalty or life in prison, during a campaign rally for congressional candidate Rick Saccone in Pennsylvania on Saturday. “I think it’s a discussion we have to start thinking about,” Trump said during the rally in Moon Township. “That means if we catch a drug dealer, death penalty,” Trump said of Singapore, recalling a conversation he had with the country’s president.



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Drug cartel violence triggers security alert for Mexican resort town

Drug cartel violence triggers security alert for Mexican resort townThe State Department has abruptly closed the U.S. consulate in Playa Del Carmen, Mexico, and is prohibiting all U.S. government employees from traveling to the resort town. Government sources tell CBS News this is because of a “real crime threat” connected to warring drug cartels. Anna Werner reports.



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The Latest: Scene of officer's killing was drug house

The Latest: Scene of officer's killing was drug houseKANSAS CITY, Mo. (AP) — The Latest on a Missouri shooting that left one police officer dead and two others wounded (all times local):



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Donald Trump hints he wants death penalty for drug dealers 

Donald Trump hints he wants death penalty for drug dealers Donald Trump has hinted that he wants to see the death penalty for drug dealers. The US president said some other countries use the "ultimate penalty" for such people and it appeared to be effective in reducing the scourge of drugs. Mr Trump was speaking at an "Opioid Summit" at the White House aimed at tackling America's opioid crisis. He said: "If you shoot one person they give you the death penalty. These people (drug dealers) can kill two or three thousand people and nothing happens to them. "The answer is you have to have strength and toughness. Drug dealers and pushers are really doing damage. "Some countries have the tough penalty, the ultimate penalty. And by the way they have much less of a drug problem than we do." Mr Trump is believed to have privately praised Singapore's policy of using the death penalty for drug traffickers. America's war against opioid addiction He is said to like the idea of America having it for major drug dealers, although to accept that such a goal may not be achievable. At the summit the president also encouraged Jeff Sessions, his Attorney General, to pursue litigation against major pharmaceutical companies manufacturing opioids. He said: "Hopefully we can do some litigation against the companies. Some of the states are doing it. I keep saying if the states are doing it why aren't the federal government doing it. So that'll happen, that'll happen."' The rate of death by drug overdose in the US has steadily risen This year an estimated 65,000 Americans will die after overdosing on opioids, whether it be prescription painkillers or illegal street drugs like heroin. That is more than die in car crashes or gun incidents, and more than the number of US soldiers that perished in the Vietnam War. The legal opioid market in America is worth around $ 15 billion a year. The US has only five per cent of the world's population, but consumes 80 per cent of all prescription painkillers. It has also been flooded with illegal and powerful synthetic opioids from China. The impact of synthetic fentanyl, a version of a drug originally intended for use by cancer patients, has been devastating. It is 50 times stronger than heroin and more than half of overdose victims now have it  in their system. Mr Trump has said the opioids crisis is a top priority for his administration. Last October he declared it a public health emergency and he recently signed a budget agreement that will provide $ 6 billion over the next two years to fight opioid abuse. 



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