Tag Archives: cancer treatment

Metformin May Lower Diabetics’ Odds for Pancreatic Cancer

Metformin, one of the most widely used diabetes drugs, may offer patients the added benefit of lowering their odds for pancreatic cancer by 60 percent, a new study shows.

But the study had a downside: Other common treatments, including the use of insulin or insulin-releasing medications such as sulfonylureas, seemed to boost diabetics’ risk for the deadly malignancy.

New Cancer Treatment Stops Aggressive Sarcomas

After all standard treatments had failed, a new cancer treatment has stopped the growth of aggressive sarcomas in two recent patients. These results are similar to the new protocol’s previous success against several cancers, including melanoma, pancreatic, colon, mesothelioma and other sarcomas.

One of the patients is an 18-year-old with malignant fibrous histiocytoma (MFH) that arose in the largest bone of his leg. The cancer spread throughout his lungs, despite aggressive surgery that replaced most of his leg with metal implants. The second patient was losing a battle with desmoplastic small round cell tumor (DSRCT), a very rare and aggressive cancer. After undergoing multiple surgical procedures and different chemotherapy regimens, the DSRCT still progressed and spread through the abdomen.

Mesothelioma – Initiation Of MORAb-009 Phase II Study In First- Line Treatment Of Mesothelioma

Morphotek(R), Inc., a subsidiary of Eisai Corporation of North America, announced that it has commenced a multi-centered Phase II study of its MORAb-009 monoclonal antibody in mesothelioma. The study will evaluate MORAb-009, plus the chemotherapy drugs pemetrexed and cisplatinum, as a first-line treatment for patients with mesothelioma cancer.

The primary objective of the study is to assess the efficacy of MORAb-009 as combination therapy with the current standard of care as determined by progression-free survival in patients with locally advanced malignant pleural mesothelioma cancer. Secondary objectives include safety and anti-tumor activity of MORAb-009 as determined by objective response rate. The patient population includes individuals with locally advanced malignant pleural mesothelioma who have not received any prior treatment for their disease. Morphotek expects to enroll up to 86 patients in this clinical study, which is being conducted at clinical centers globally.